#Doxylamine insomnia pregnancy full#

The Preferred Reporting Items for Systematic Reviews and Metaanalyses format for the literature search process is diagrammed in the Figure. This resulted in a total of 16 articles to use. Of these 399 articles, we scanned the titles and abstracts and narrowed inclusion further by excluding articles in which prescription reason or dose was specified outside of the sedative realm. After removing duplicate articles from the multiple searches, we had 399 articles to review. These exclusions removed a substantial number from our potential article pool and resulted in 1055 articles.

#Doxylamine insomnia pregnancy full#

Thus, we excluded results that were animal studies, neonatal studies, reviews, inaccessible full texts, non-English publications, or for-medication doses that fell outside of the FDA-specified hypnotic/sedative doses. Our primary focus was to summarize comprehensively the current literature on medications that are used for sedative or hypnotic purposes by pregnant women. These search terms, which allowed for 30 different searches, resulted in 1452 articles. , mirtazapine, trazodone, diphenhydramine, doxylamine, hydroxyzine, pheniramines ).

We exhaustively searched PubMed and found articles based on key search terms: pregnancy and sleep with various medications or drug classes ( hypnotics, sedatives, benzodiazepine, nonbenzodiazepine, melatonin, antidepressants, antihistamines, ramelteon, zolpidem, zopiclone, zaleplon, alprazolam, clonazepam lorazepam, medazepam, nitrazepam, temazepam, tofisopam.